User:Stephanie Maung/Sandbox
From Proteopedia
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H6831 Fab complex binds to a highly accessible region near the C-terminus of OspB, away from the N-terminus lipid anchor. The Fab makes contact at three exposed, adjacent . The interaction of OspB-Fab complex depends heavily on hydrogen bonding between loops 1,2 and 3. When binding of full-length OspB and Fab fragments of H6831 or CB2 fail, it is usually because lys-253, located on loop 2, has been replaced with a different residue. Studies show that substitutions in basic residues of hen egg-white lysozyme (HEL) that participate in HEL-Fab complexes decreased binding affinity by 400-10,000 times.
Residues 157 - 201 contain the of OspB upon interaction with Fab H6831.
