3vmx

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Template:STRUCTURE 3vmx

Contents 1 Crystal Structure of a parallel coiled-coil dimerization domain from the voltage-gated proton channel 2 Function 3 About this Structure 4 Reference

Crystal Structure of a parallel coiled-coil dimerization domain from the voltage-gated proton channel

Template:ABSTRACT PUBMED 22569364

Function

[HVCN1_MOUSE] Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis (By similarity).

About this Structure

3vmx is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

• Fujiwara Y, Kurokawa T, Takeshita K, Kobayashi M, Okochi Y, Nakagawa A, Okamura Y. The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H(+) channel Hv1. Nat Commun. 2012 May 8;3:816. doi: 10.1038/ncomms1823. PMID:22569364 doi:10.1038/ncomms1823