2e6f

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Template:STRUCTURE 2e6f

Contents

Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with oxonate

Function

[PYRD_TRYCC] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.

About this Structure

2e6f is a 2 chain structure with sequence from Trycr. Full crystallographic information is available from OCA.

See Also

Reference

  • Inaoka DK, Sakamoto K, Shimizu H, Shiba T, Kurisu G, Nara T, Aoki T, Kita K, Harada S. Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction. Biochemistry. 2008 Oct 14;47(41):10881-91. Epub 2008 Sep 23. PMID:18808149 doi:10.1021/bi800413r

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