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4fk3

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Image:4fk3.jpg

Template:STRUCTURE 4fk3

B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX3203

Template:ABSTRACT PUBMED 18287029

About this Structure

4fk3 is a 2 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 3c4d. Full crystallographic information is available from OCA.

Reference

  • Tsai J, Lee JT, Wang W, Zhang J, Cho H, Mamo S, Bremer R, Gillette S, Kong J, Haass NK, Sproesser K, Li L, Smalley KS, Fong D, Zhu YL, Marimuthu A, Nguyen H, Lam B, Liu J, Cheung I, Rice J, Suzuki Y, Luu C, Settachatgul C, Shellooe R, Cantwell J, Kim SH, Schlessinger J, Zhang KY, West BL, Powell B, Habets G, Zhang C, Ibrahim PN, Hirth P, Artis DR, Herlyn M, Bollag G. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3041-6. Epub 2008 Feb 19. PMID:18287029

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