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2lvz
From Proteopedia
Contents |
Solution structure of a Eosinophil Cationic Protein-trisaccharide heparin mimetic complex
Template:ABSTRACT PUBMED 23025322
Function
[ECP_HUMAN] Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.[1] [2]
About this Structure
2lvz is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Garcia-Mayoral MF, Canales A, Diaz D, Lopez-Prados J, Moussaoui M, de Paz JL, Angulo J, Nieto PM, Jimenez-Barbero J, Boix E, Bruix M. Insights into the glycosaminoglycan-mediated cytotoxic mechanism of eosinophil cationic protein revealed by NMR. ACS Chem Biol. 2013 Jan 18;8(1):144-51. doi: 10.1021/cb300386v. Epub 2012 Oct 9. PMID:23025322 doi:10.1021/cb300386v
- ↑ Gabay JE, Scott RW, Campanelli D, Griffith J, Wilde C, Marra MN, Seeger M, Nathan CF. Antibiotic proteins of human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5610-4. PMID:2501794
- ↑ Torrent M, de la Torre BG, Nogues VM, Andreu D, Boix E. Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment. Biochem J. 2009 Jul 15;421(3):425-34. doi: 10.1042/BJ20082330. PMID:19450231 doi:10.1042/BJ20082330
