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1w2k
From Proteopedia
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TF7A_4380 COMPLEX
Overview
Proof of concept experiments have shown that tissue factor/factor VIIa, inhibitors have antithrombotic activity without enhancing bleeding, propensity. Starting from lead compounds generated by a biased, combinatorial approach, phenylglycine amide tissue factor/factor VIIa, inhibitors with low nanomolar affinity and good selectivity against other, serine proteases of the coagulation cascade were designed, using the, guidance of X-ray structural analysis and molecular modelling.
About this Structure
1W2K is a [Protein complex] structure of sequences from [Homo sapiens] with FUC, BGC, CA, CAC and 380 as [ligands]. Active as [Coagulation factor VIIa], with EC number [3.4.21.21]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors., Groebke Zbinden K, Banner DW, Ackermann J, D'Arcy A, Kirchhofer D, Ji YH, Tschopp TB, Wallbaum S, Weber L, Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. PMID:15664864
Page seeded by OCA on Tue Oct 30 16:22:52 2007
Categories: Coagulation factor VIIa | Homo sapiens | Protein complex | Ackermann, J. | Arcy, A.D. | Banner, D.W. | Groebke-Zbinden, K. | Ji, Y. | Kirchhofer, D. | Tschopp, T.B. | Wallbaum, S. | Weber, L. | 380 | BGC | CA | CAC | FUC | Blood coagulation | Calcium-binding | Co-factor | Coagulation | Enzyme complex | Gamma-carboxyglutamic acid | Glycoprotein | Hydrolase | Plasma | Serine protease | Vitamin k
