This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1bnl

From Proteopedia

Revision as of 08:13, 20 March 2008 by OCA (Talk | contribs)
Jump to: navigation, search
Image:1bnl.gif


PDB ID 1bnl

Drag the structure with the mouse to rotate
, resolution 2.9Å
Ligands:
Gene: COLLAGEN XVIII (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN


Contents

Overview

The crystal structure of human endostatin reveals a zinc-binding site. Atomic absorption spectroscopy indicates that zinc is a constituent of both human and murine endostatin in solution. The human endostatin zinc site is formed by three histidines at the N terminus, residues 1, 3, and, 11, and an aspartic acid at residue 76. The N-terminal loop ordered around the zinc makes a dimeric contact in human endostatin crystals. The location of the zinc site at the amino terminus, immediately adjacent to the precursor cleavage site, suggests the possibility that the zinc may be involved in activation of the antiangiogenic activity following cleavage from the inactive collagen XVIII precursor or in the cleavage process itself.

Disease

Known disease associated with this structure: Knobloch syndrome OMIM:[120328]

About this Structure

1BNL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Zinc-dependent dimers observed in crystals of human endostatin., Ding YH, Javaherian K, Lo KM, Chopra R, Boehm T, Lanciotti J, Harris BA, Li Y, Shapiro R, Hohenester E, Timpl R, Folkman J, Wiley DC, Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10443-8. PMID:9724722

Page seeded by OCA on Thu Mar 20 10:13:21 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1bnl"
Personal tools