1a9u

From Proteopedia

proteopedia linkproteopedia link

spinqualitylabelsall models PDB ID 1a9u Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1a9u, resolution 2.50Å ()
Ligands:
Structural annotation: Resources: CATH : 1A9U001, 1A9U002 InterPro : Ipr003527, Ipr008352, Ipr002290, Ipr008271, Ipr000719, Ipr011009 Pfam : PF00069 SCOP : d1a9u__ UniProt : Q16539
Functional annotation: Cellular component: cytoplasm nucleus Biological process: protein amino acid phosphorylation protein kinase cascade cell surface receptor linked signal transduction cell motility response to stress chemotaxis signal transduction Molecular function: protein kinase activity MP kinase activity transferase activity nucleotide binding MAP kinase kinase activity protein binding kinase activity ATP binding MAP kinase activity protein serine/threonine kinase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Contents 1 THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB203580 2 About this Structure 3 See Also 4 Reference

THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB203580

Template:ABSTRACT PUBMED 9753691

About this Structure

1a9u is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Mitogen-activated protein kinase

Reference

• Wang Z, Canagarajah BJ, Boehm JC, Kassisa S, Cobb MH, Young PR, Abdel-Meguid S, Adams JL, Goldsmith EJ. Structural basis of inhibitor selectivity in MAP kinases. Structure. 1998 Sep 15;6(9):1117-28. PMID:9753691
• Avvakumov GV, Walker JR, Xue S, Finerty PJ Jr, Mackenzie F, Newman EM, Dhe-Paganon S. Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8). J Biol Chem. 2006 Dec 8;281(49):38061-70. Epub 2006 Oct 11. PMID:17035239 doi:10.1074/jbc.M606704200