3cde

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Template:STRUCTURE 3cde

Contents 1 Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor 2 About this Structure 3 See Also 4 Reference

Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor

Template:ABSTRACT PUBMED 18457949

About this Structure

3cde is a 2 chain structure of RNA polymerase with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

See Also

• RNA polymerase

Reference

• Li LS, Zhou Y, Murphy DE, Stankovic N, Zhao J, Dragovich PS, Bertolini T, Sun Z, Ayida B, Tran CV, Ruebsam F, Webber SE, Shah AM, Tsan M, Showalter RE, Patel R, Lebrun LA, Bartkowski DM, Nolan TG, Norris DA, Kamran R, Brooks J, Sergeeva MV, Kirkovsky L, Zhao Q, Kissinger CR. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)- 5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3446-55. Epub 2008 Mar 5. PMID:18457949 doi:10.1016/j.bmcl.2008.02.072