1e4j

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spinqualitylabelsall models PDB ID 1e4j Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
, resolution 2.5Å
Coordinates:	save as pdb, mmCIF, xml

CRYSTAL STRUCTURE OF THE SOLUBLE HUMAN FC-GAMMA RECEPTOR III

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

The immune response depends on the binding of opsonized antigens to cellular Fc receptors and the subsequent initiation of various cellular effector functions of the immune system. Here we describe the crystal structures of a soluble Fc gamma receptor (sFc gammaRIII, CD16), an Fc fragment from human IgG1 (hFc1) and their complex. In the 1:1 complex the receptor binds to the two halves of the Fc fragment in contact with residues of the C gamma2 domains and the hinge region. Upon complex formation the angle between the two sFc gammaRIII domains increases significantly and the Fc fragment opens asymmetrically. The high degree of amino acid conservation between sFc gammaRIII and other Fc receptors, and similarly between hFc1 and related immunoglobulins, suggest similar structures and modes of association. Thus the described structure is a model for immune complex recognition and helps to explain the vastly differing affinities of other Fc gammaR-IgG complexes and the Fc epsilonRI alpha-IgE complex.

Disease

Known diseases associated with this structure: Lupus erythematosus, systemic, susceptibility OMIM:[146740], Neutropenia, alloimmune neonatal OMIM:[146740], Viral infections, recurrent OMIM:[146740]

About this Structure

1E4J is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex., Sondermann P, Huber R, Oosthuizen V, Jacob U, Nature. 2000 Jul 20;406(6793):267-73. PMID:10917521

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