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spinqualitylabelsall models PDB ID 1g5m Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1g5m, 1 NMR models ()
Related:	1bxl, 1g5j, 1g5o
Structural annotation: Resources: CATH : 1G5Ma00 InterPro : Ipr004725, Ipr013278, Ipr003093, Ipr000712, Ipr002475, Ipr012238 Pfam : PF00452 SCOP : d1g5ma_ UniProt : P10415
Functional annotation: Cellular component: mitochondrial outer membrane membrane cytoplasm nucleus endoplasmic reticulum nuclear membrane mitochondrion cytosol integral to membrane Biological process: response to nicotine regulation of mitochondrial membrane potential pigmentation anti-apoptosis negative regulation of mitochondrial depolarization response to radiation regulation of mitochondrial membrane permeability regulation of protein homodimerization activity response to iron ion response to toxin female pregnancy regulation of protein heterodimerization activity hair follicle morphogenesis apoptosis positive regulation of cell proliferation regulation of apoptosis humoral immune response defense response to virus negative regulation of neuron apoptosis negative regulation of cellular pH reduction release of cytochrome c from mitochondria negative regulation of apoptosis neuron apoptosis regulation of viral genome replication Molecular function: protein heterodimerization activity identical protein binding protein binding protease binding protein homodimerization activity BH3 domain binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 HUMAN BCL-2, ISOFORM 1 2 About this Structure 3 See Also 4 Reference

HUMAN BCL-2, ISOFORM 1

Template:ABSTRACT PUBMED 11248023

About this Structure

1g5m is a 1 chain structure of Bcl-2 and Horseradish peroxidase with sequence from Homo sapiens. Full experimental information is available from OCA.

See Also

• Bcl-2
• Horseradish peroxidase

Reference

• Petros AM, Medek A, Nettesheim DG, Kim DH, Yoon HS, Swift K, Matayoshi ED, Oltersdorf T, Fesik SW. Solution structure of the antiapoptotic protein bcl-2. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3012-7. Epub 2001 Feb 27. PMID:11248023 doi:10.1073/pnas.041619798