Molecular dynamics simulations of the thermal stability of tteRBP and ecRBP
Xian-li Feng, Xi Zhao, Hui Yu, Tie-dong Sun, Xu-ri Huang [1]
Molecular Tour
The backbone structure of tteRBP (optimal activity temperature is 375 K) and ecRBP (optimal activity temperature is 329K) is very similar, but significantly
different in thermal stability. This is particularly attractive us.
In order to investigate the thermal stability of tteRBP and ecRBP, we found the backboneuse flexibility and verify the side-chain interactions both are the key factors to maintain thermal stability of the two proteins by molecular dynamics (MD)simulation method.
