3ufy

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Template:STRUCTURE 3ufy

Contents

AKR1C3 complex with R-naproxen

Template:ABSTRACT PUBMED 22937138

Function

[AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

About this Structure

3ufy is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.

See Also

Reference

  • Flanagan JU, Yosaatmadja Y, Teague RM, Chai MZ, Turnbull AP, Squire CJ. Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3. PLoS One. 2012;7(8):e43965. doi: 10.1371/journal.pone.0043965. Epub 2012 Aug 28. PMID:22937138 doi:http://dx.doi.org/10.1371/journal.pone.0043965

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