1jch

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spinqualitylabelsall models PDB ID 1jch Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
, resolution 3.02Å
Ligands:	and
Coordinates:	save as pdb, mmCIF, xml

Crystal Structure of Colicin E3 in Complex with its Immunity Protein

Overview

Colicins kill E. coli by a process that involves binding to a surface receptor, entering the cell, and, finally, intoxicating it. The lethal action of colicin E3 is a specific cleavage in the ribosomal decoding A site. The crystal structure of colicin E3, reported here in a binary complex with its immunity protein (IP), reveals a Y-shaped molecule with the receptor binding domain forming a 100 A long stalk and the two globular heads of the translocation domain (T) and the catalytic domain (C) comprising the two arms. Active site residues are D510, H513, E517, and R545. IP is buried between T and C. Rather than blocking the active site, IP prevents access of the active site to the ribosome.

About this Structure

1JCH is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of colicin E3: implications for cell entry and ribosome inactivation., Soelaiman S, Jakes K, Wu N, Li C, Shoham M, Mol Cell. 2001 Nov;8(5):1053-62. PMID:11741540

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