2vfa

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Template:STRUCTURE 2vfa

Contents 1 Crystal structure of a chimera of Plasmodium falciparum and human hypoxanthine-guanine phosphoribosyl transferases 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal structure of a chimera of Plasmodium falciparum and human hypoxanthine-guanine phosphoribosyl transferases

Template:ABSTRACT PUBMED 18536021

Function

[HGXR_PLAFG] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Works with guanine, hypoxanthine and xanthine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.

About this Structure

2vfa is a 2 chain structure with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

See Also

• Phosphoribosyltransferase

Reference

• Gayathri P, Sujay Subbayya IN, Ashok CS, Selvi TS, Balaram H, Murthy MR. Crystal structure of a chimera of human and Plasmodium falciparum hypoxanthine guanine phosphoribosyltransferases provides insights into oligomerization. Proteins. 2008 Dec;73(4):1010-20. PMID:18536021 doi:10.1002/prot.22129