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3u6c

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Template:STRUCTURE 3u6c

Contents

MutM set 1 ApGo

Template:ABSTRACT PUBMED 22465958

Function

[P84131_GEOSE] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS020629_004_120556]

About this Structure

3u6c is a 3 chain structure with sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

  • Sung RJ, Zhang M, Qi Y, Verdine GL. SEQUENCE-DEPENDENT STRUCTURAL VARIATION IN DNA UNDERGOING INTRAHELICAL INSPECTION BY MUTM. J Biol Chem. 2012 Mar 30. PMID:22465958 doi:10.1074/jbc.M111.313635

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