Investigation on the Site-Selective Binding of Bovine Serum Albumin by Erlotinib Hydrochloride
Yan Liu, Mingmao Chen, Zhipu Luo, Jingjing Lin, Ling Song [1]
Molecular Tour
The binding mode of , a targeted anticancer drug, to was investigated through 1H NMR, spectroscopic, thermodynamic and molecular modeling methods. Each subdomain is marked with a different colour (red for subdomain IA; orange, IB; cyan, IIA; yellow, IIB; green, IIIA; darkmagenta, IIIB). From these methods, the binding parameters, binding site, binding distance, and conformational changes were obtained. Site marker competitive experiments demonstrated that the . The docking modeling agreed with the results of the fluorescence and displacement experiments.
