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4axf
From Proteopedia
Contents |
InsP5 2-K in complex with Ins(3,4,5,6)P4 plus AMPPNP
Template:ABSTRACT PUBMED 22745128
Function
[IPPK_ARATH] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.[1] [2]
About this Structure
4axf is a 1 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.
Reference
- Banos-Sanz JI, Sanz-Aparicio J, Whitfield H, Hamilton C, Brearley CA, Gonzalez B. Conformational Changes in Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase upon Substrate Binding: ROLE OF N-TERMINAL LOBE AND ENANTIOMERIC SUBSTRATE PREFERENCE. J Biol Chem. 2012 Aug 24;287(35):29237-49. Epub 2012 Jun 28. PMID:22745128 doi:10.1074/jbc.M112.363671
- ↑ Stevenson-Paulik J, Bastidas RJ, Chiou ST, Frye RA, York JD. Generation of phytate-free seeds in Arabidopsis through disruption of inositol polyphosphate kinases. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12612-7. Epub 2005 Aug 17. PMID:16107538 doi:10.1073/pnas.0504172102
- ↑ Sweetman D, Johnson S, Caddick SE, Hanke DE, Brearley CA. Characterization of an Arabidopsis inositol 1,3,4,5,6-pentakisphosphate 2-kinase (AtIPK1). Biochem J. 2006 Feb 15;394(Pt 1):95-103. PMID:16223361 doi:BJ20051331
