Sandbox Reserved 390

From Proteopedia

Revision as of 02:39, 19 September 2012 by Eyitayo Akoda (Talk | contribs)
Jump to: navigation, search

Human topoisomerase IIbeta in complex with DNA and etoposide

Insert caption here

Drag the structure with the mouse to rotate

Crystal structure of a large fragment of human type II topoisomerases (TOP2) complexed to DNA and to the anticancer drug etoposide to reveal structural details of drug-induced stabilization of a cleavage complex. The interplay between the protein, the DNA, and the drug explains the structure-activity relations of etoposide derivatives and the molecular basis of drug-resistant mutations. [1]

References

  1. ↑ Wu CC, Li TK, Farh L, Lin LY, Lin TS, Yu YJ, Yen TJ, Chiang CW, Chan NL. Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide. Science. 2011 Jul 22;333(6041):459-62. PMID:21778401 doi:10.1126/science.1204117
Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_Reserved_390"
Personal tools