4e4k
From Proteopedia
Crystal Structure of PPARgamma with the ligand JO21
Template:ABSTRACT PUBMED 23171045
About this Structure
4e4k is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Montanari R, Saccoccia F, Scotti E, Crestani M, Godio C, Gilardi F, Loiodice F, Fracchiolla G, Laghezza A, Tortorella P, Lavecchia A, Novellino E, Mazza F, Aschi M, Pochetti G. Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design. J Med Chem. 2008 Dec 25;51(24):7768-76. PMID:19053776 doi:10.1021/jm800733h
- Li Y, Wang Z, Furukawa N, Escaron P, Weiszmann J, Lee G, Lindstrom M, Liu J, Liu X, Xu H, Plotnikova O, Prasad V, Walker N, Learned RM, Chen JL. T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties. J Biol Chem. 2008 Apr 4;283(14):9168-76. Epub 2008 Feb 7. PMID:18263587 doi:10.1074/jbc.M800104200
