2k6b is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Human programmed cell death 5 (PDCD5) is a translocatory protein playing an important role in the apoptotic process of cells. Although there are accumulated data about PDCD5 function, the correlation of the structure with the function of PDCD5 has not been investigated. Here, we report the studies of structure-function relationship of PDCD5 by multidimensional NMR methods and by FACScan flow cytometer and fluorescence microscope. The 3D structure of intact PDCD5 and the internal motions of PDCD5 have been determined. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal region and a flexible unstructured C-terminal region. The flow cytometry and internalization measurements of different PDCD5 fragments indicate that the charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. Combined analyses reveal a fact that the regions that seem to be most involved in the function also are more flexible in PDCD5.
Structure-function correlation of human programmed cell death 5 protein.,Yao H, Xu L, Feng Y, Liu D, Chen Y, Wang J Arch Biochem Biophys. 2009 Jun 15;486(2):141-9. Epub 2009 Apr 7. PMID:19358820[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Yao H, Xu L, Feng Y, Liu D, Chen Y, Wang J. Structure-function correlation of human programmed cell death 5 protein. Arch Biochem Biophys. 2009 Jun 15;486(2):141-9. Epub 2009 Apr 7. PMID:19358820 doi:10.1016/j.abb.2009.03.018
