1ga3

From Proteopedia

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Template:STRUCTURE 1ga3

Contents 1 NMR STRUCTURE OF INTERLEUKIN-13 2 Disease 3 Function 4 About this Structure 5 See Also 6 Reference

NMR STRUCTURE OF INTERLEUKIN-13

Template:ABSTRACT PUBMED 11419949

Disease

[IL13_HUMAN] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.

Function

[IL13_HUMAN] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

About this Structure

1ga3 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

See Also

• Interleukin

Reference

• Eisenmesser EZ, Horita DA, Altieri AS, Byrd RA. Solution structure of interleukin-13 and insights into receptor engagement. J Mol Biol. 2001 Jun 29;310(1):231-41. PMID:11419949 doi:http://dx.doi.org/10.1006/jmbi.2001.4765