1nez

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Template:STRUCTURE 1nez

Contents 1 The Crystal Structure of a TL/CD8aa Complex at 2.1A resolution:Implications for Memory T cell Generation, Co-receptor Preference and Affinity 2 Function 3 About this Structure 4 See Also 5 Reference

The Crystal Structure of a TL/CD8aa Complex at 2.1A resolution:Implications for Memory T cell Generation, Co-receptor Preference and Affinity

Template:ABSTRACT PUBMED 12594948

Function

[HA1T_MOUSE] Involved in the presentation of foreign antigens to the immune system. [CD8A_MOUSE] Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. [B2MG_MOUSE] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

About this Structure

1nez is a 4 chain structure. Full crystallographic information is available from OCA.

See Also

• Beta-2 microglobulin
• CD8
• Major histocompatibility complex

Reference

• Liu Y, Xiong Y, Naidenko OV, Liu JH, Zhang R, Joachimiak A, Kronenberg M, Cheroutre H, Reinherz EL, Wang JH. The crystal structure of a TL/CD8alphaalpha complex at 2.1 A resolution: implications for modulation of T cell activation and memory. Immunity. 2003 Feb;18(2):205-15. PMID:12594948