1svm

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spinqualitylabelsall models PDB ID 1svm Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1svm, resolution 1.94Å ()
Ligands:	, ,
Related:	1svl, 1svo
Structural annotation: Resources: CATH : 1Svma03, 1Svma01, 1Svmb01, 1Svmb03, 1Svmc01, 1Svmc03, 1Svmd01, 1Svmd03, 1Svme01, 1Svme03, 1Svmf01, 1Svmf03 InterPro : Ipr014015, Ipr010932, Ipr003133, Ipr001623 Pfam : PF06431 UniProt : P03070
Functional annotation: Cellular component: nucleus Biological process: DNA replication Molecular function: ATP binding heat shock protein binding metal ion binding nucleotide binding zinc ion binding DNA binding DNA replication origin binding protein binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Co-crystal structure of SV40 large T antigen helicase domain and ATP 2 About this Structure 3 See Also 4 Reference

Co-crystal structure of SV40 large T antigen helicase domain and ATP

Template:ABSTRACT PUBMED 15454080

About this Structure

1svm is a 6 chain structure with sequence from Simian virus 40. The August 2006 RCSB PDB Molecule of the Month feature on AAA+ Proteases by David S. Goodsell is 10.2210/rcsb_pdb/mom_2006_8. Full crystallographic information is available from OCA.

See Also

• ATPase
• Journal:JSB:1
• Large T Antigen

Reference

• Gai D, Zhao R, Li D, Finkielstein CV, Chen XS. Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen. Cell. 2004 Oct 1;119(1):47-60. PMID:15454080 doi:10.1016/j.cell.2004.09.017
• Lilyestrom W, Klein MG, Zhang R, Joachimiak A, Chen XS. Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor. Genes Dev. 2006 Sep 1;20(17):2373-82. PMID:16951253 doi:http://dx.doi.org/20/17/2373
• Steere AN, Byrne SL, Chasteen ND, Smith VC, Macgillivray RT, Mason AB. Evidence that His349 acts as a pH-inducible switch to accelerate receptor-mediated iron release from the C-lobe of human transferrin. J Biol Inorg Chem. 2010 Aug 14. PMID:20711621 doi:10.1007/s00775-010-0694-2 20711621 10.1007/s00775-010-0694-2