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1ptr
From Proteopedia
Revision as of 20:47, 28 September 2014 by OCA (Talk | contribs)
1ptr is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Protein kinase Cs (PKCs) are a ubiquitous family of regulatory enzymes that associate with membranes and are activated by diacylglycerol or tumor-promoting agonists such as phorbol esters. The structure of the second activator-binding domain of PKC delta has been determined in complex with phorbol 13-acetate, which binds in a groove between two pulled-apart beta strands at the tip of the domain. The C3, C4, and C20 phorbol oxygens form hydrogen bonds with main-chain groups whose orientation is controlled by a set of highly conserved residues. Phorbol binding caps the groove and forms a contiguous hydrophobic surface covering one-third of the domain, explaining how the activator promotes insertion of PKC into membranes.
Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester.,Zhang G, Kazanietz MG, Blumberg PM, Hurley JH Cell. 1995 Jun 16;81(6):917-24. PMID:7781068[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Zhang G, Kazanietz MG, Blumberg PM, Hurley JH. Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester. Cell. 1995 Jun 16;81(6):917-24. PMID:7781068
