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2jom
From Proteopedia
Contents |
NMR structure of rabbit prion protein mutation I214V
Template:ABSTRACT PUBMED 20949107
Disease
[PRIO_RABIT] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
Function
[PRIO_RABIT] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
About this Structure
2jom is a 1 chain structure with sequence from Oryctolagus cuniculus. Full experimental information is available from OCA.
See Also
Reference
- Wen Y, Li J, Xiong M, Peng Y, Yao W, Hong J, Lin D. Solution structure and dynamics of the I214V mutant of the rabbit prion protein. PLoS One. 2010 Oct 7;5(10):e13273. PMID:20949107 doi:10.1371/journal.pone.0013273
