2kia

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Template:STRUCTURE 2kia

Contents 1 Solution structure of Myosin VI C-terminal cargo-binding domain 2 Disease 3 Function 4 About this Structure 5 See Also 6 Reference

Solution structure of Myosin VI C-terminal cargo-binding domain

Template:ABSTRACT PUBMED 19665975

Disease

[MYO6_MOUSE] Note=Defects in Myo6 are the cause of Snell's waltzer, a condition characterized by circling, head-tossing, deafness and hyperactivity.

Function

[MYO6_MOUSE] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells.

About this Structure

2kia is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA.

See Also

• Myosin

Reference

• Yu C, Feng W, Wei Z, Miyanoiri Y, Wen W, Zhao Y, Zhang M. Myosin VI undergoes cargo-mediated dimerization. Cell. 2009 Aug 7;138(3):537-48. PMID:19665975 doi:10.1016/j.cell.2009.05.030