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1oe4

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Template:STRUCTURE 1oe4

Contents

Xenopus SMUG1, an anti-mutator uracil-DNA Glycosylase

Template:ABSTRACT PUBMED 12820976

Function

[SMUG1_XENLA] Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. No enzymatic activity towards G/T mismatches.

About this Structure

1oe4 is a 4 chain structure with sequence from Xenopus laevis. Full crystallographic information is available from OCA.

See Also

Reference

  • Wibley JE, Waters TR, Haushalter K, Verdine GL, Pearl LH. Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1. Mol Cell. 2003 Jun;11(6):1647-59. PMID:12820976

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OCA

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