1h5o

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Template:STRUCTURE 1h5o

Contents 1 Solution structure of Crotamine, a neurotoxin from Crotalus durissus terrificus 2 Function 3 About this Structure 4 See Also 5 Reference

Solution structure of Crotamine, a neurotoxin from Crotalus durissus terrificus

Template:ABSTRACT PUBMED 12709056

Function

[MYXC_CRODU] This toxin specifically modifies voltage-gated sodium channels (Nav), it exhibits analgesic activity and causes severe muscle necrosis by a non-enzymatic mechanism. Moreover, it actively interacts with lipid membranes.^{[1] [2]}

About this Structure

1h5o is a 1 chain structure with sequence from Crotalus durissus terrificus. Full experimental information is available from OCA.

See Also

• Crotamine

Reference

• Nicastro G, Franzoni L, de Chiara C, Mancin AC, Giglio JR, Spisni A. Solution structure of crotamine, a Na+ channel affecting toxin from Crotalus durissus terrificus venom. Eur J Biochem. 2003 May;270(9):1969-79. PMID:12709056

1. ↑ Laure CJ. [The primary structure of crotamine (author's transl)]. Hoppe Seylers Z Physiol Chem. 1975 Feb;356(2):213-5. PMID:1176086
2. ↑ Mancin AC, Soares AM, Andriao-Escarso SH, Faca VM, Greene LJ, Zuccolotto S, Pela IR, Giglio JR. The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study. Toxicon. 1998 Dec;36(12):1927-37. PMID:9839677