3fhc

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Template:STRUCTURE 3fhc

Contents 1 Crystal structure of human Dbp5 in complex with Nup214 2 Disease 3 Function 4 About this Structure 5 See Also 6 Reference

Crystal structure of human Dbp5 in complex with Nup214

Template:ABSTRACT PUBMED 19219046

Disease

[NU214_HUMAN] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.

Function

[NU214_HUMAN] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. [DD19B_HUMAN] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.

About this Structure

3fhc is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Helicase
• Nucleoporin

Reference

• von Moeller H, Basquin C, Conti E. The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner. Nat Struct Mol Biol. 2009 Feb 15. PMID:19219046 doi:nsmb.1561