Publication Abstract from PubMed
The structure of a truncated variant of casein kinase-1 from Schizosaccharomyces pombe, has been determined in complex with MgATP at 2.0 A resolution. The model resembles the 'closed', ATP-bound conformations of the cyclin-dependent kinase 2 and the cAMP-dependent protein kinase, with clear differences in the structure of surface loops that impart unique features to casein kinase-1. The structure is of unphosphorylated, active conformation of casein kinase-1 and the peptide-binding site is fully accessible to substrate.
Crystal structure of casein kinase-1, a phosphate-directed protein kinase.,Xu RM, Carmel G, Sweet RM, Kuret J, Cheng X EMBO J. 1995 Mar 1;14(5):1015-23. PMID:7889932[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
