3lw2

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Template:STRUCTURE 3lw2

Contents

Mouse Plasminogen Activator Inhibitor-1 (PAI-1)

Template:ABSTRACT PUBMED 20230900

Function

[PAI1_MOUSE] Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis (By similarity).

About this Structure

3lw2 is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Dewilde M, Van De Craen B, Compernolle G, Madsen JB, Strelkov S, Gils A, Declerck PJ. Subtle structural differences between human and mouse PAI-1 reveal the basis for biochemical differences. J Struct Biol. 2010 Mar 15. PMID:20230900 doi:10.1016/j.jsb.2010.03.006

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OCA

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