3b9k

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Template:STRUCTURE 3b9k

Contents

Crystal structure of CD8alpha-beta in complex with YTS 156.7 FAB

Template:ABSTRACT PUBMED 18929574

Function

[CD8B_MOUSE] Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. [CD8A_MOUSE] Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

About this Structure

3b9k is a 8 chain structure with sequence from Mus musculus and Rattus rattus. Full crystallographic information is available from OCA.

See Also

Reference

  • Shore DA, Issafras H, Landais E, Teyton L, Wilson IA. The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I. J Mol Biol. 2008 Dec 31;384(5):1190-202. Epub 2008 Oct 7. PMID:18929574 doi:10.1016/j.jmb.2008.09.069

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