3hb8

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Template:STRUCTURE 3hb8

Contents 1 Structures of Thymidylate Synthase R163K with Substrates and Inhibitors Show Subunit Asymmetry 2 Function 3 About this Structure 4 See Also 5 Reference

Structures of Thymidylate Synthase R163K with Substrates and Inhibitors Show Subunit Asymmetry

Template:ABSTRACT PUBMED 21206062

Function

[TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.^[1]

About this Structure

3hb8 is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Thymidylate synthase

Reference

• Gibson LM, Celeste LR, Lovelace LL, Lebioda L. Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding. Acta Crystallogr D Biol Crystallogr. 2011 Jan;67(Pt 1):60-6. Epub 2010 Dec 16. PMID:21206062 doi:10.1107/S0907444910044732

1. ↑ Anderson DD, Quintero CM, Stover PJ. Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15163-8. doi:, 10.1073/pnas.1103623108. Epub 2011 Aug 26. PMID:21876188 doi:10.1073/pnas.1103623108