3b7x

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 3b7x

Contents 1 Crystal structure of human FK506-Binding Protein 6 2 Disease 3 Function 4 About this Structure 5 See Also

Crystal structure of human FK506-Binding Protein 6

Disease

[FKBP6_HUMAN] Note=FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

Function

[FKBP6_HUMAN] PPIases accelerate the folding of proteins.

About this Structure

3b7x is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Cyclophilin