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3bnz

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Template:STRUCTURE 3bnz

Contents

Crystal structure of Thymidylate Synthase ternary complex with dUMP and 8A inhibitor

Template:ABSTRACT PUBMED 21696158

Function

[TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.

About this Structure

3bnz is a 1 chain structure with sequence from Lactobacillus casei. Full crystallographic information is available from OCA.

See Also

Reference

  • Mangani S, Cancian L, Leone R, Pozzi C, Lazzari S, Luciani R, Ferrari S, Costi MP. Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening. J Med Chem. 2011 Aug 11;54(15):5454-67. Epub 2011 Jul 12. PMID:21696158 doi:10.1021/jm2005018

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OCA

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