| Structural highlights
1lwc is a 2 chain structure with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | ,
| | NonStd Res: | |
| Related: | 1vrt, 1rth, 1vru, 1rti, 1rtj, 1rev, 1rt1, 1rt2, 1klm, 1rt3, 1rt4, 1rt5, 1rt6, 1rt7, 1c0t, 1c0u, 1c1b, 1c1c, 1dtq, 1dtt, 1ep4, 1fk9, 1fko, 1fkp, 1jla, 1jlb, 1jlc, 1jle, 1jlf, 1jlg, 1jkh, 1jlq, 1lw0, 1lw2, 1lwe, 1lwf |
| Gene: | HIV-1 POL (Human immunodeficiency virus 1) |
| Activity: | RNA-directed DNA polymerase, with EC number 2.7.7.49 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Six structures of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) containing combinations of resistance mutations for zidovudine (AZT) (M41L and T215Y) or lamivudine (M184V) have been determined as inhibitor complexes. Minimal conformational changes in the polymerase or nonnucleoside RT inhibitor sites compared to the mutant RTMC (D67N, K70R, T215F, and K219N) are observed, indicating that such changes may occur only with certain combinations of mutations. Model building M41L and T215Y into HIV-1 RT-DNA and docking in ATP that is utilized in the pyrophosphorolysis reaction for AZT resistance indicates that some conformational rearrangement appears necessary in RT for ATP to interact simultaneously with the M41L and T215Y mutations.
Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.,Chamberlain PP, Ren J, Nichols CE, Douglas L, Lennerstrand J, Larder BA, Stuart DI, Stammers DK J Virol. 2002 Oct;76(19):10015-9. PMID:12208978[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Chamberlain PP, Ren J, Nichols CE, Douglas L, Lennerstrand J, Larder BA, Stuart DI, Stammers DK. Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215. J Virol. 2002 Oct;76(19):10015-9. PMID:12208978
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