This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1bn0
From Proteopedia
Revision as of 09:34, 13 August 2014 by OCA (Talk | contribs)
An NMR-based structure is presented for a 20 mer hairpin model of the SL3 stem-loop from the HIV-1 packaging signal. The stem has an A-family structure. However, the GGAG tetraloop appears to be flexible with the second (G10) and fourth (G12) bases extruded from the normal stacking arrangement. The A-base (A11) occupies a cavity large enough for it to jump rapidly between stacking upon G9 (in the loop) and G13 (from the base-pair adjacent to the loop). The H-bonding loci of G10, A11, and G12 are unoccupied in the free RNA structure. The loop should be easily adaptable to binding by the HIV-1 nucleocapsid protein or loop receptors.
Three-dimensional folding of an RNA hairpin required for packaging HIV-1.,Pappalardo L, Kerwood DJ, Pelczer I, Borer PN J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:9743628[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Pappalardo L, Kerwood DJ, Pelczer I, Borer PN. Three-dimensional folding of an RNA hairpin required for packaging HIV-1. J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:9743628 doi:http://dx.doi.org/S0022-2836(98)92046-0
