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1bvj
From Proteopedia
Revision as of 09:48, 13 August 2014 by OCA (Talk | contribs)
1bvj is a 1 chain structure with sequence from Viruses. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Interaction of HIV-1 genomic RNA and human tRNA(Lys)3 initiates viral reverse transcription. An adenosine-rich (A-rich) loop in HIV RNA mediates complex formation between tRNA and viral RNA. We have determined the structure of an A-rich loop oligonucleotide using nuclear magnetic resonance spectroscopy. The loop structure is stabilized by a noncanonical G-A pair and a U-turn motif, which leads to stacking of the conserved adenosines. The structure has similarity to the tRNA anticodon structure, and suggests possible mechanisms for its role in initiation of reverse transcription.
