Acetyl-CoA synthetase

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Template:STRUCTURE 2p2j

Acetyl-CoA synthetase (ACS) catalyzes the ligation of acetate and CoA to form acetyl-CoA with the conversion of ATP to AMP and pyrophosphate. The acetyl-CoA is used in aerobic respiration to produce energy and electron carriers and for lipid biosynthesis. ACS is an ATP-dependent AMP-binding enzyme.

3D structures of acetyl-CoA synthetase

1pg3, 1pg4 – ACS (mutant) + CoA + AMP – Salmonella enterica
2p20, 2p2m, 2p2q - StACS (mutant) + AMP – Salmonella typhimurium
2p2b, 2p2j - StACS (mutant) + CoA + AMP
2p2f - StACS + CoA + AMP
1ry2 – ACS + AMP - yeast

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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