1dst

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Template:STRUCTURE 1dst

Contents

MUTANT OF FACTOR D WITH ENHANCED CATALYTIC ACTIVITY

Template:ABSTRACT PUBMED 7592653

Disease

[CFAD_HUMAN] Defects in CFD are the cause of complement factor D deficiency (CFDD) [MIM:613912]. CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.

Function

[CFAD_HUMAN] Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

About this Structure

1dst is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Kim S, Narayana SV, Volanakis JE. Crystal structure of a complement factor D mutant expressing enhanced catalytic activity. J Biol Chem. 1995 Oct 13;270(41):24399-405. PMID:7592653

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