Sandbox Reserved 647

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Revision as of 05:19, 13 November 2012 by Ehab Rahman (Talk | contribs)
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Pyruvate Dehydrogenase E1 Component

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This Sandbox is Reserved from 30/08/2012, through 01/02/2013 for use in the course "Proteins and Molecular Mechanisms" taught by Robert B. Rose at the North Carolina State University, Raleigh, NC USA. This reservation includes Sandbox Reserved 636 through Sandbox Reserved 685.
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Pyruvate dehydrogenase (E1) along with two other subunits make up the multienzyme complex pyruvate dehydrogenase. Dihydrolipoyl transacetylase (E2) and dihydrolipoyl dehydrogenase (E3) are the other two main components of the complex. These enzymes work together to synthesize acetyl Co-A from pyruvate before entering the Kreb's cycle. The pyruvate dehydrogenase complex acts to link glycolysis to the citric acid cycle.


Pyruvate dehydrogenase consists of a combination of beta strands and alpha helices. this is the site of between three residues of pyruvate dehydrogenase.

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