Structural highlights
Publication Abstract from PubMed
The first cell-penetrating peptide that activates protein phosphatase-1 (PP1) by disrupting a subset of PP1 complexes in living cells has been developed. Activated PP1 rapidly dephosphorylates its substrates, counteracting kinase activity inside cells. Activation of PP1 can thus be a novel approach to study PP1 function and to counteract Ser/Thr kinase activity under pathologically increased kinase signaling.
Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells.,Chatterjee J, Beullens M, Sukackaite R, Qian J, Lesage B, Hart DJ, Bollen M, Kohn M Angew Chem Int Ed Engl. 2012 Sep 7. doi: 10.1002/anie.201204308. PMID:22962028[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Chatterjee J, Beullens M, Sukackaite R, Qian J, Lesage B, Hart DJ, Bollen M, Kohn M. Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells. Angew Chem Int Ed Engl. 2012 Sep 7. doi: 10.1002/anie.201204308. PMID:22962028 doi:http://dx.doi.org/10.1002/anie.201204308
