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1ial
From Proteopedia
Revision as of 11:29, 28 September 2014 by OCA (Talk | contribs)
1ial is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Importin alpha is the nuclear import receptor that recognizes classical monopartite and bipartite nuclear localization signals (NLSs). The structure of mouse importin alpha has been determined at 2.5 A resolution. The structure shows a large C-terminal domain containing armadillo repeats, and a less structured N-terminal importin beta-binding domain containing an internal NLS bound to the NLS-binding site. The structure explains the regulatory switch between the cytoplasmic, high-affinity form, and the nuclear, low-affinity form for NLS binding of the nuclear import receptor predicted by the current models of nuclear import. Importin beta conceivably converts the low- to high-affinity form by binding to a site overlapping the autoinhibitory sequence. The structure also has implications for understanding NLS recognition, and the structures of armadillo and HEAT repeats.
Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha.,Kobe B Nat Struct Biol. 1999 Apr;6(4):388-97. PMID:10201409[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Kobe B. Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha. Nat Struct Biol. 1999 Apr;6(4):388-97. PMID:10201409 doi:10.1038/7625
