4g35

From Proteopedia

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Template:STRUCTURE 4g35

Contents 1 Mcl-1 in complex with a biphenyl cross-linked Noxa peptide. 2 Function 3 About this Structure 4 Reference

Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.

Template:ABSTRACT PUBMED 22920569

Function

[MCL1_MOUSE] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.

About this Structure

4g35 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

• Muppidi A, Doi K, Edwardraja S, Drake EJ, Gulick AM, Wang HG, Lin Q. Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors. J Am Chem Soc. 2012 Sep 12;134(36):14734-7. doi: 10.1021/ja306864v. Epub 2012 Sep, 4. PMID:22920569 doi:10.1021/ja306864v