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1kug

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Template:STRUCTURE 1kug

Contents

Crystal Structure of a Taiwan Habu Venom Metalloproteinase complexed with its endogenous inhibitor pENW

Template:ABSTRACT PUBMED 12071970

Function

[VM2T3_PROMU] Snake venom metalloproteinase TM-3: fibrin(ogen)olytic protease which cleaves the Aalpha chain of fibrinogen (FGA) first followed by the Bbeta chain (FGB) and shows relatively low activity on the gamma chain (FGG).[1] [2] Disintegrin trimucrin: inhibits platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).[3] [4]

About this Structure

1kug is a 2 chain structure with sequence from Protobothrops mucrosquamatus. Full crystallographic information is available from OCA.

Reference

  • Huang KF, Chiou SH, Ko TP, Wang AH. Determinants of the inhibition of a Taiwan habu venom metalloproteinase by its endogenous inhibitors revealed by X-ray crystallography and synthetic inhibitor analogues. Eur J Biochem. 2002 Jun;269(12):3047-56. PMID:12071970
  1. ↑ Tsai IH, Wang YM, Lee YH. Characterization of a cDNA encoding the precursor of platelet aggregation inhibition and metalloproteinase from Trimeresurus mucrosquamatus venom. Biochim Biophys Acta. 1994 Aug 18;1200(3):337-40. PMID:8068721
  2. ↑ Huang KF, Hung CC, Chiou SH. Characterization of three fibrinogenolytic proteases isolated from the venom of Taiwan habu (Trimeresurus mucrosquamatus). Biochem Mol Biol Int. 1993 Dec;31(6):1041-50. PMID:8193588
  3. ↑ Tsai IH, Wang YM, Lee YH. Characterization of a cDNA encoding the precursor of platelet aggregation inhibition and metalloproteinase from Trimeresurus mucrosquamatus venom. Biochim Biophys Acta. 1994 Aug 18;1200(3):337-40. PMID:8068721
  4. ↑ Huang KF, Hung CC, Chiou SH. Characterization of three fibrinogenolytic proteases isolated from the venom of Taiwan habu (Trimeresurus mucrosquamatus). Biochem Mol Biol Int. 1993 Dec;31(6):1041-50. PMID:8193588

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