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1kcm
From Proteopedia
Contents |
Crystal Structure of Mouse PITP Alpha Void of Bound Phospholipid at 2.0 Angstroms Resolution
Template:ABSTRACT PUBMED 11980708
Disease
[PIPNA_MOUSE] Note=Defects in Pitpna are the cause of the vibrator phenotype which is characterized by early-onset progressive action tremor, degeneration of brain stem and spinal cord neurons, and juvenile death. The mutation is due to the insertion of an intracisternal A particle retrotransposon in intron 4 which results in a 5-fold reduction in protein levels.
Function
[PIPNA_MOUSE] Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.
About this Structure
1kcm is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Schouten A, Agianian B, Westerman J, Kroon J, Wirtz KW, Gros P. Structure of apo-phosphatidylinositol transfer protein alpha provides insight into membrane association. EMBO J. 2002 May 1;21(9):2117-21. PMID:11980708 doi:http://dx.doi.org/10.1093/emboj/21.9.2117
