1k78

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Template:STRUCTURE 1k78

Contents

Pax5(1-149)+Ets-1(331-440)+DNA

Template:ABSTRACT PUBMED 11779502

Disease

[PAX5_HUMAN] Note=A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6.

Function

[ETS1_MOUSE] Transcription factor. [PAX5_HUMAN] May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.

About this Structure

1k78 is a 9 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Garvie CW, Hagman J, Wolberger C. Structural studies of Ets-1/Pax5 complex formation on DNA. Mol Cell. 2001 Dec;8(6):1267-76. PMID:11779502

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