2lkq

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Template:STRUCTURE 2lkq

Contents 1 NMR structure of the lambda 5 22-45 peptide 2 Disease 3 Function 4 About this Structure 5 Reference

NMR structure of the lambda 5 22-45 peptide

Template:ABSTRACT PUBMED 23124203

Disease

[IGLL1_HUMAN] Defects in IGLL1 are the cause of agammaglobulinemia type 2 (AGM2) [MIM:613500]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.

Function

[IGLL1_HUMAN] Critical for B-cell development.^[1]

About this Structure

2lkq is a 1 chain structure. Full experimental information is available from OCA.

Reference

1. ↑ Minegishi Y, Coustan-Smith E, Wang YH, Cooper MD, Campana D, Conley ME. Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia. J Exp Med. 1998 Jan 5;187(1):71-7. PMID:9419212