Glutathione S-transferase

spinqualitylabelsall models Human glutathione S-transferase class α complex with glutathione (PDB entry 1pkw) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Glutathione S-transferase (GST) catalyzes the conjugation of reduced glutathione (GSH) to a variety of exogenous and endogenous hydrophobic electrophiles. For example, GST can detoxify peroxidised lipids. All eukaryotes possess a variety of GSTs with catalytic and non-catalytic activities. GST is divided into classes: α, δ, ε, κ, μ, ν, ω, π, ρ, σ (hematopoietic prostaglandin D synthase), τ, χ, ϑ, ζ and microsomal.

Contents 1 GST 2 GST binary complex with GSH 3 GST binary complex 4 GST α class 5 GST α class complex with GSH 6 GST α class complex 7 GST δ class 8 GST ε class 9 GST κ class 10 GST μ class 11 GST μ class complex with GSH 12 GST μ class complex 13 GST ν class 14 GST π class 15 GST π class complex with GSH 16 GST π class complex 17 GST ρ class 18 GST σ class 19 GST ϑ class 20 GST χ class 21 GST ω class 22 GST ζ class 23 GST τ class 24 Microsomal GST

GST

4hz4 – GST – Actinobacillus pleuropneumoniae'Italic text
1gsb, 1gsc – rGST – rat
3ubk – LiGST – Leptospira interrogans
3uap - GST – Methylococcus capsulatus
1aw9 - cGST III – corn
1okt – PfGST – Plasmodium falciparum
3fr6 - PfGST (mutant)
1tw9 – GST - Heligmosomoides polygyrus
1yq1 - CeGST – Caenorhabditis elegans
1y6e - SjGST – Schistosoma japonicum
2fno, 3lq7 - AtGST – Agrobacterium tumefaciens
2on7 – NaGST-1 – Necator americanus
3erf - yGST II – yeast
3f6f – DmGST – Drosophila melanogaster
3lxt - PsfGST – Pseudomonas fluorescens
4eci - PaGST – Pseudomonas aeruginosa
3niv - GST – Legionella pneumophila
3tot - RsGST – Ralstonia solanacearum
3ay8 - siGST – silkworm
3uap - McGST – Methylococcus capsulatus

GST binary complex with GSH

2x64 – GST + GSH – Xylella fastidiosa
4hz2 - GST + GSH - Xanthobacter autotrophicus
4ecj - PaGST + GSH
1fhe, 2fhe - GST + GSH – Fasciola hepatica
1pmt, 2pmt - GST + GSH – Proteus mirabilis
1m0u, 3gh6 - DmGST + GSH
1oe7, 1oe8 - ShGST + GSH – Schistosoma haematobium
1u3i - GST + GSH - Schistosoma mansoni
1oyj - GST + GSH - rice
1u87 - SjGST + GSH
2dsa, 2gdr - GST + GSH – Burkholderia xenovorans
2on5 – NaGST-2 + GSH
2nto - OaGST + GSH – Ochrobactrum anthropi
2pvq - OaGST (mutant) + GSH
3ibh - yGST II + GSH
3fr9 - PfGST + GSH
3m3m - PsfGST + GSH
3lsz - GST + GSH – Rhodobacter sphaeroides
3n5o - GST + GSH – Coccidioides immitis
3tou - RsGST + GSH
3uar - McGST + GSH
4g9h, 4gci - GST + GSH – Yersinia pestis
4gf0 - GST + GSH - Sulfitobacter

GST binary complex

3ubl - LiGST + GSH derivative
2gsq – GST + GSH derivative – squid
2gst, 3gst, 4gst, 5gst, 1gss - rGST + GSH derivative
1gnw - AtGST + GSH derivative – Arabidopsis thaliana
1aqv - hGST + GSH derivative – human
1gtb, 1gta - SjGST + praziquantel
1m99, 1m9a, 1m9b - SjGST + GSH derivative
1q4j, 2aaw, 3frc - PfGST + GSH derivative
3fr3 - PfGST (mutant) + GSH derivative
1bx9 - AtGST + herbicide
1bye - cGST I + herbicide
1axd – cGST I + lactoyl-GSH
1a0f, 1n2a - GST + GSH derivative – Eschericia coli
1f2e - GST + GSH derivative
– Sphingomonas paucimobilis
1mtc - rGST + GSH derivative
1ua5 - SjGST + GSH derivative
1u88 - SjGST (mutant) + GSH derivative
3erg - yGST II + GSH derivative
3qmz - yGST + dynein heavy chain
2ycd - AtGST + GSH derivative

GST α class

1guh, 1gsd, 1k3o, 1pkz – hGST A1-1
1xwg, 3q74, 3u6v - hGST A1-1 (mutant)
1gum - hGST A4-4
1guk - mGST A4-4 – mouse
1vf4 - GgGST A1-1 - chicken

GST α class complex with GSH

1pkw - hGST + GSH
1usb - hGST (mutant) + GSH
1f3a - mGST A1-1+ GSH
3i69, 3i6a - hGST A1-1 (mutant)+ GSH
2wju - hGST A2-2 + GSH
4acs - hGST A2-2 (mutant) + GSH
1tdi - hGST A3-3 + GSH
1vf1 - GgGST A1-1 + GSH

GST α class complex

1gsf – hGST A1-1 + ethacrynic acid
1ags, 1pl2, 1ydk, 2r3x, 2r6k, 3ktl, 3l0h – hGST (mutant) + GSH derivative
1k3l, 1k3y, 1pl1 - hGST + GSH derivative
1gse – hGST (mutant) + GSH + ethacrynic acid
3ik9 - hGST A1-1 + GSDN
2vct - hGST A2-2 + steroid
2vcv - hGST A3-3 + steroid
1gul - hGST A4-4+ iodobenzyl-GSH
3ik7 - hGST A4-4 + GSDHN
1b48 - mGST A4-4 + GSH derivative
1f3b - mGST A1-1 + GSH derivative
1ml6 - mGST A2-2+ GSH derivative
1ev4, 1ev9 - rGST A1-1 (mutant) + GSH derivative
1vf2, 1vf3 – GgGST A1-1 + GSH derivative

GST δ class

1r5a, 1v2a, 1pn9 - GST + GSH derivative - Anopheles cracens
3ein - DmGST + GSH
3vk9 - siGST

GST ε class

2il3 - AgGST – Anopheles gambiae
2imi - AgGST + GSH
2imk - AgGST + GSH derivative

GST κ class

3rpp - hGST
1r4w - rGST + GSH derivative
1yzx, 3rpn - hGST + GSH derivative

GST μ class

1gsb, 1gsc – rGST
6gsu, 6gsv, 6gsw, 6gsx, 6gsy, 5fwg, 3fyg - rGST (mutant)
1gtu, 2gtu, 3gtu, 4gtu - hGST
2dc5 - mGST
2wrt - GST – Fasciola hepatica

GST μ class complex with GSH

1xw5, 1xw6 - hGST + GSH
2f8f - mGST (mutant) + GSH
3crt - SjGST + GSH
3cru, 3d0z - SjGST (mutant) + GSH

GST μ class complex

1gst - GgGST + GSH derivative
1c72 - GgGST + conjugate
1hna, 1hnb, 1hnc, 1xwk, 1ykc, 1yj6, 2ab6, 2f3m – hGST + GSH derivative
2c4j - hGST (mutant) + GSH derivative
1b4p - rGST + GSH derivative
3gur - hGST + GSH + drug
3gus - hGST + drug

GST ν class

2ws2 - GST – Haemonchus contortus

GST π class

1bay - mGST
10gs, 14gs, 16gs, 1lbk - hGST
22gs, 1eog, 1eoh, 3hjm, 3hkr, 3kmn - hGST (mutant)

GST π class complex with GSH

1gsy - mGST + GSH
1tu7, 2hnl - OvGST + GSH - Onchocerca volvulus
5gss, 6gss, 7gss, 8gss, 19gs, 3dd3 - hGST + GSH
1md3, 1md4, 1px6, 1px7, 1kbn - hGST (mutant) + GSH
3t2u - GST + GSH – Wuchereria bancrofti

GST π class complex

1gss – rGST + GSH derivative
1tu8 - OvGST + GSH derivative
1glq, 1glp, 2glr, 1gti - mGST + GSH derivative
2oac, 2oad, 2oa7, 3o76 - mGST (mutant) + GSH derivative
2gss, 3dgq – hGST + ethacrynic acid
3n9j - hGST + ethacrynic acid derivative
3gss, 11gs – hGST + ethacrynic acid + GSH
3hjo, 3km6, 3kmo - hGST (mutant) + ethacrynic acid + GSH
1pgt, 2pgt, 4gss, 17gs, 2j9h, 3csi - hGST (mutant) + GSH derivative
1aqw, 1aqx, 9gss, 12gs, 18gs, 3pgt, 4pgt, 1zgn, 2a2r, 2a2s, 3csh - hGST + GSH derivative
20gs - hGST + cibacron blue
13gs, 3csj - hGST + drug
3ie3 - hGST (mutant) + drug

GST ρ class

3qav - AcGST – Atlantic clam
3qaw - AcGST + GSH

GST σ class

2c8u, 2cai - ShGST (mutant)
2ca8 - ShGST + GSH
1zl9 - CeGST + GSH
4ec0, 4edz, 4ee0, 4edy, 1iyh, 1iyi, 2vcq, 2vcw, 2vcx, 2vcz, 2vd0, 2vd1 - hGST + GSH
3vi7 - hGST (mutant) + GSH
1v40, 2cvd, 3ee2, 3kxo - hGST + GSH + inhibitor
3vi5, 3vi7 - hGST (mutant) + GSH + inhibitor
2caq - ShGST (mutant) + GSH
1pd2 - rGST + GSH
2c80 - ShGST + GSH derivative

GST ϑ class

2ljr, 2c3n - hGST
2c3t - hGST (mutant)
1ljr - hGST + GSH
3mak - DmGST + GSH
3ljr - hGST + GSH derivative
2c3q - hGST (mutant) + GSH derivative

GST χ class

3ppu - GST + GSH – Phanerochaete chrysosporium

GST ω class

1eem – hGST
3q18, 3vln - hGST (mutant)
3rbt - siGST
3lfl - hGST + GSH
3qag, 3q19 - hGST (mutant) + GSH

GST ζ class

1e6b – AtGST
2cz3 - mGST
2cz2 - mGST + GSH

GST τ class

1gwc - GST – wheat
2vo4 - sGST + GSH derivative – soybean
3fhs - sGST + GSH

Microsomal GST

2h8a - rGST + GSH